Iloperidone for Bipolar Disorder

Most recent medication to be approved for bipolar disorder is an atypical anti-psychotic, Iloperidone. To be more specific, this drug was approved by the US Food and Drug Administration for treatment of manic or mixed episodes associated with bipolar I disorder in adults. This can be considered a significant development because new medications and treatments in the field of psychiatry are few.

Iloperidone is an atypical anti-psychotic, with a mixed D2/5HT2A antagonism as its mechanism of action. It was first approved for acute treatment of schizophrenia in adults. 

References:

•  Vanda Pharmaceuticals' Fanapt (iloperidone) receives US FDA approval for the acute treatment of bipolar I disorder. News release. Vanda Pharmaceuticals Inc. April 2, 2024. Accessed April 2, 2024. https://www.prnewswire.com/news-releases/vanda-pharmaceuticals-fanapt-iloperidone-receives-us-fda-approval-for-the-acute-treatment-of-bipolar-i-disorder-302106405.html
• Torres R, Czeisler EL, Chadwick SR, Stahl SM, Smieszek SP, Xiao C, Polymeropoulos CM, Birznieks G, Polymeropoulos MH. Efficacy and Safety of Iloperidone in Bipolar Mania: A Double-Blind, Placebo-Controlled Study. J Clin Psychiatry. 2024 Jan 15;85(1):23m14966. doi: 10.4088/JCP.23m14966. PMID: 38236020.