Saturday, September 25, 2021

Treatment of Malaria In India - Update part 1

I had posted treatment guidelines for malaria in 2014, as per the existing guidelines. 

Newer guidelines have been introduced since. Hence, this update. 

1. Treatment of Uncomplicated Plasmodium Falciparum Malaria 

Artemisinin combination therapy (ACT) is the drug of choice for all confirmed cases of uncomplicated PF cases. This should be combined with primaquine (PQ) (0.75 mg/kg body weight or 45 mg) on day-2. The ACT recommended in the National Program in India is artesunate (AS) + sulfadoxine and pyrimethamine (SP). Oral AS monotherapy is banned in India.

2. Treatment of Uncomplicated Plasmodium Vivax malaria

Chloroquine is the drug of choice of Plasmodium vivax (PV) cases. It is given at a dose of 10 mg/kg (600 mg) on day-1 and day-2 and 300 mg on day-3. Primaquine at a dose of 0.25 mg/kg (15 mg/day) for 14 days is tobe added to prevent relapse. Primaquine is contraindicated in G6PD deficiency cases, infants and pregnant women.

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